Synthesis of quinazolinone scaffolds a zinc(II)-stabilized amidyl radical-promoted deaminative approach.

Herein, we report a solely ligand centered redox controlled protocol, utilizing a bench stable zinc compound, for the efficient coupling of -amino amides/esters with nitriles to afford diverse quinazolinone scaffolds and their synthetic utility was showcased post-modification to access therapeutically relevant compounds. Importantly, mechanistic probes established the reaction pathway that proceeds aminyl radical.