Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Increasing evidence suggests that long noncoding RNAs play crucial roles in lung cancer pathogenesis. We previously identified a novel lncRNA, , which is associated with tumor cell proliferation. In the present study, we find that knockdown of inhibits cell proliferation, migration and invasion as well as tumor formation both and in nude mice. silencing also improves cisplatin efficacy in A549/DDP cells. The function of may depend on its interaction with YBX1. Knockdown of reduces the recruitment of YBX1 to the promoter and delays tumor progression through its coregulatory genes, which are mainly involved in the p53 signaling pathway. We utilize nebulized inhalation to deliver siRNAs targeting and find that significantly prevents tumor metastasis and growth in lung tissues. These findings reveal the role of in lung cancer and suggest a promising therapeutic approach involving siRNA inhalation.
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| http://dx.doi.org/10.3724/abbs.2024093 | DOI Listing |
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