Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11184256PMC
http://dx.doi.org/10.1016/j.ekir.2024.03.027DOI Listing

Publication Analysis

Top Keywords

response [challenging
4
[challenging restrictive
4
restrictive approach
4
approach reconsidering
4
reconsidering sglt-2
4
sglt-2 inhibitor
4
inhibitor ckd]
4
response
1
restrictive
1
approach
1

Similar Publications

Introduction: The sense of smell is one of the most developed and important senses that forms the bond between the newborn and the mother and allows the newborn to reach the mother's breast. The sense of smell begins to form during intrauterine life, and the sense of smell can be a marking tool for a newborn baby, so that the baby can recognize both his mother and his immediate environment and develop his behaviour accordingly. This is necessary not only for feeding babies but also for them to feel safe and peaceful in their new environment.

View Article and Find Full Text PDF

The incident angle of seismic waves influences the dynamic response of rock slopes. However, the relationship between the back-slope effect in strong earthquake areas and the incident angle has not been well-explained. Based on the equivalent nodal force method and the viscoelastic artificial boundary theory, the oblique incidence of seismic P-wave and SV-wave are carried out in FLAC3D software.

View Article and Find Full Text PDF

Optimizing T cell inflamed signature through a combination biomarker approach for predicting immunotherapy response in NSCLC.

Sci Rep

December 2024

Interventional Oncology, Johnson & Johnson Enterprise Innovation, Inc, 10th Floor 255 Main St, 02142, Cambridge, Boston, MA, USA.

The introduction of anti-PD-1/PD-L1 therapies revolutionized treatment for advanced non-small cell lung cancer (NSCLC), yet response rates remain modest, underscoring the need for predictive biomarkers. While a T cell inflamed gene expression profile (GEP) has predicted anti-PD-1 response in various cancers, it failed in a large NSCLC cohort from the Stand Up To Cancer-Mark (SU2C-MARK) Foundation. Re-analysis revealed that while the T cell inflamed GEP alone was not predictive, its performance improved significantly when combined with gene signatures of myeloid cell markers.

View Article and Find Full Text PDF

Studies of in situ plant response and adaptation to complex environmental stresses, are crucial for understanding the mechanisms of formation and functioning of ecosystems of anthropogenically transformed habitats. We study short- and long-term responses of photosynthetic apparatus (PSA) and anti-oxidant capacity to complex abiotic stresses of common plants Calamagrostis epigejos and Solidago gigantea in semi-natural (C) and heavy metal contaminated habitats (LZ). We found significant differences in leaf pigment content between both plant species growing on LZ plots and their respective C populations.

View Article and Find Full Text PDF

Identification and validation of up-regulated TNFAIP6 in osteoarthritis with type 2 diabetes mellitus.

Sci Rep

December 2024

Division of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.

Lines of evidence have indicated that type 2 diabetes mellitus (T2DM) is an independent risk factor for osteoarthritis (OA) progression. However, the study focused on the relationship between T2DM and OA at the transcriptional level remains empty. We downloaded OA- and T2DM-related bulk RNA-sequencing and single-cell RNA sequencing data from the Gene Expression Omnibus (GEO) dataset.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!