AI Article Synopsis
- Fluorinated heterocycles are crucial in pharmaceuticals, with about 20% of anticancer and antibiotic drugs containing fluorine atoms, prompting this review of five-membered and benzo-fused systems with fluorine.
- These compounds have demonstrated notable anticancer and antimicrobial activities, with some serving as lead structures for drug development, showing efficacy comparable to or better than existing drugs.
- Studies indicate that the type of substituents on these fluorinated heterocycles (electron-donating or electron-withdrawing) greatly influences their biological activity and safety profiles, showcasing reduced cytotoxicity in non-cancerous cells.
Article Abstract
Due to the importance of the fluorinated heterocycles as main components of marketed drugs where 20% of the anticancer and antibiotic drugs contain fluorine atoms, this review describes the reported five-membered heterocycles and their benzo-fused systems having directly connected fluorine atom(s). The and anticancer and antimicrobial activities of these fluorinated heterocycles are well reported. Some fluorinated heterocycles were found to be lead structures for drug design developments where their activities were almost equal to or exceeded the potency of the reference drugs. In most cases, the fluorine-containing heterocycles showed promising safety index their reduced cytotoxicity in non-cancerous cell lines. SAR study assigned that fluorinated heterocycles having various electron-donating or electron-withdrawing substituents significantly affected the anticancer and antimicrobial activities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11185950 | PMC |
| http://dx.doi.org/10.1039/d4ra01387e | DOI Listing |
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