Vasc Med
Current: Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Published: June 2024
Introduction: Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic cause of myocardial infarction. Migraine headache has been reported to be common among patients with SCAD, but the degree of migraine-related disability has not been quantified.
Methods: Clinical data and headache variables were obtained from the baseline assessment of the prospective, multicenter iSCAD Registry. Migraine-related disability was quantified using the self-reported Migraine Disability Assessment (MIDAS). Demographic, clinical, psychosocial, and medical characteristics from data entry forms were compared between patients with and without migraine.
Results: Of the 773 patients with available data, 46% reported previous or current migraines. Those with migraines were more likely to be women (96.9% vs 90.3%, = 0.0003). The presence of underlying carotid fibromuscular dysplasia was associated with migraine (35% vs 27%, = 0.0175). There was not a significant association with carotid artery dissection and migraine. Current migraine frequency was less than monthly (58%), monthly (24%), weekly (16%), and daily (3%). Triptan use was reported in 32.5% of patients, and 17.5% used daily migraine prophylactic medications. Using the MIDAS to quantify disability related to migraine, 60.2% reported little or no disability, 14.4% mild, 12.7% moderate, and 12.7% severe. The mean MIDAS score was 9.9 (mild to moderate disability). Patients with SCAD had higher rates of depression and anxiety (28.2% vs 17.7% [ = 0.0004] and 35.3% vs 26.7% [ = 0.0099], respectively).
Conclusions: Migraines are common, frequent, and a source of disability in patients with SCAD. The association between female sex, anxiety, and depression may provide some insight for potential treatment modalities.
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http://dx.doi.org/10.1177/1358863X241252444 | DOI Listing |
J Clin Med
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Internal Medicine Department, Faculty of Medicine, Ovidius University of Constanta, 145 Tomis Boulevard, 900591 Constanta, Romania.
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Klinik für diagnostische und interventionelle Neuroradiologie, Universitätskliniken des Saarlandes, Kirrberger Str., 66421, Homburg Saar, Deutschland.
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Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK.
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