AI Article Synopsis
- A phase II clinical trial investigated the effectiveness and safety of a treatment combining camrelizumab with modified TPF chemotherapy for patients with locally advanced hypopharyngeal squamous cell carcinoma (LA HSCC).
- The study included 51 patients who received three cycles of chemoimmunotherapy, resulting in an objective response rate of 82.4% and showing promising interim survival outcomes for two years.
- Although there were some significant adverse events, no treatment-related deaths were reported, indicating that the therapy has a favorable safety profile.
Article Abstract
This phase II trial aimed to determine the efficacy and safety of induction chemoimmunotherapy of camrelizumab plus modified TPF in locally advanced hypopharyngeal squamous cell carcinoma (LA HSCC) (NCT04156698). The primary endpoint was objective response rate (ORR), and secondary endpoints were 3-year overall survival (OS), progression-free survival (PFS), larynx preservation rate (LPR), and metastasis-free survival (MFS). Patients (cT3-4aN0-2M0), regardless of sex, received induction chemoimmunotherapy for three cycles: camrelizumab 200 mg d1, docetaxel 75 mg/m d1, cisplatin 25 mg/m d1-3, and capecitabine 800 mg/m bid d1-14, q21d. Patients were assigned to radioimmunotherapy if they had a complete or partial response, those with stable or progressive disease underwent surgery and adjuvant (chemo)radiotherapy. Camrelizumab was maintained post-radioimmunotherapy. Fifty-one patients were enrolled with a median follow-up duration of 23.7 months. After induction therapy, the ORR was 82.4% (42/51), meeting the prespecified endpoint. Grade 3/4 adverse events occurred in 26 patients, and no treatment-related death occurred. As three-year outcomes were immature, two-year OS, PFS and LPR were reported. As no distant metastatic event had occurred, MFS was not reported here. The two-year OS, PFS, and LPR rates were 83.0%, 77.1%, and 70.0%, respectively. The induction chemoimmunotherapy of camrelizumab plus TPF showed a high ORR rate with an acceptable safety profile in LA HSCC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11187213 | PMC |
| http://dx.doi.org/10.1038/s41467-024-49121-3 | DOI Listing |
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