AI Article Synopsis
- N-acetylcysteine, a known antioxidant, can help counteract the harmful effects of pesticides like pyrimiphos-methyl in a mouse model.
- The study showed that N-acetylcysteine significantly lowers oxidative stress caused by this pesticide.
- Combining N-acetylcysteine with traditional treatments like atropine and obidoxime does not interfere with its antioxidant benefits, suggesting it could enhance safety during pesticide poisoning treatments.
Article Abstract
Exogenous, well-established antioxidant N-acetylcysteine can reduce or prevent the deleterious effects of pesticides. In this study, utilizing a mouse model of daily single dose of N-acetylcysteine administration, we investigated the impact of this adjuvant on the treatment with atropine and/or obidoxime as well as oxidative stress response in pyrimiphos-methyl-induced toxicity. We found that N-acetylcysteine significantly reduces the oxidative stress generated by pyrimiphos-methyl. The therapy consisting of atropine and/or obidoxime routinely used in organophosphorous insecticide poisonings, including pyrimiphos-methyl, had no effect on the antioxidant properties of N-acetylcysteine. Adjunctive treatment offered by N-acetylcysteine fills therapeutic gap and may provide the full potential against pyrimiphos-methyl-induced toxicity.
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| http://dx.doi.org/10.1111/bcpt.14044 | DOI Listing |
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