AI Article Synopsis
- - The study investigates the link between infections and the development of Parkinson's disease (PD), finding that hospital-treated infections increase PD risk, notably from neurological and lower respiratory infections.
- - Data from the UK Biobank were used to assess the impact of infection burden over time and specific types of infections on PD incidence, revealing a dose-response relationship with increasing infection episodes correlating with higher PD risk.
- - Both observational and genetic analyses suggest a causal link between infections and PD, highlighting the need for further research in this area.
Article Abstract
Background: Experimental and cross-sectional evidence has suggested a potential role of infection in the ethology of Parkinson's disease (PD). We aim to examine the longitudinal association of infections with the incidence of PD and to explore whether the increased risk is limited to specific infection type rather than infection burden.
Methods: Based on the UK Biobank, hospital-treated infectious diseases and incident PD were ascertained through record linkage to national hospital inpatient registers. Infection burden was defined as the sum of the number of infection episodes over time and the number of co-occurring infections. The polygenic risk score (PRS) for PD was calculated. The genome-wide association studies (GWAS) used in two-sample Mendelian Randomization (MR) were obtained from observational cohort participants of mostly European ancestry.
Results: Hospital-treated infectious diseases were associated with an increased risk of PD (adjusted HR [aHR] 1.35 [95 % CI 1.20-1.52]). This relationship persisted when analyzing new PD cases occurring more than 10 years post-infection (aHR 1.22 [95 % CI 1.04-1.43]). The greatest PD risk was observed in neurological/eye infection (aHR 1.72 [95 % CI 1.32-2.34]), with lower respiratory tract infection (aHR 1.43 [95 % CI 1.02-1.99]) ranked the second. A dose-response association was observed between infection burden and PD risk within each PD-PRS tertile (p-trend < 0.001). Multivariable MR showed that bacterial and viral infections increase the PD risk.
Conclusions: Both observational and genetic analysis suggested a causal association between infections and the risk of developing PD. A dose-response relationship between infection burden and incident PD was revealed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbi.2024.06.016 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of CCR5Δ32 on the risk of infection, Staphylococcus aureus carriage, and plasma concentrations of chemokines in Danish blood donors.
EBioMedicine
November 2024
Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Article Synopsis
- The CCR5 receptor is linked to susceptibility to Staphylococcus aureus leukotoxin ED, and researchers investigated the effects of the CCR5Δ32 deletion on S. aureus infection and nasal carriage in a large Danish blood donor study.
- Analysis involved over 95,000 participants, examining various health outcomes and inflammatory markers through sophisticated statistical methods.
- Findings indicated that CCR5Δ32 does not significantly affect the risk of S. aureus-related infections or nasal carriage, although it was associated with higher levels of certain chemokines in individuals with the deletion.
Association between self-reported child maltreatment and risk of hospital-treated infectious diseases in middle-aged and older adults: A UK Biobank cohort study.
Prev Med
December 2024
Department of Biostatistics, Key Laboratory for Health Technology Assessment, National Commission of Health, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address:
Article Synopsis
- - This study examined how child maltreatment affects the risk of hospital-treated infectious diseases in adults aged 38-72, using data from over 145,000 participants in the UK Biobank from 2006 to 2010.
- - Results revealed that individuals who experienced any type of maltreatment faced a higher risk of infectious diseases, with the risk increasing based on the number of maltreatment types; those with multiple forms of maltreatment were particularly vulnerable.
- - The study concluded that early prevention of child maltreatment is crucial, as it appears to lead to an increased susceptibility to various infectious diseases later in life, influenced by factors like inflammation, mental health issues, and unhealthy lifestyles.
Hospital-Treated Infectious Diseases, Infection Burden, and Risk of Lung Cancer: An Observational and Mendelian Randomization Study.
Chest
January 2025
Bioscience and Biomedical Engineering Thrust (J. Z. and S.T.), Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China; Division of Emerging Interdisciplinary Areas (S. T.), Center for Aging Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. Electronic address:
Background: Although infections play a role in the development of lung cancer, the longitudinal association between infection and the risk of lung cancer is disputed, and data relating to pathogen types and infection sites are sparse.
Research Question: How do infections affect subsequent lung cancer risk, and is the impact limited to specific microbes rather than infection burden?
Study Design And Methods: Data on > 900 infectious diseases were gathered from the UK Biobank study. Short- and long-term effects of infections were assessed by using time-varying Cox proportional hazards models.
Hospital-treated infectious diseases, genetic susceptibility and risk of type 2 diabetes: A population-based longitudinal study.
Diabetes Metab Syndr
June 2024
Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, Guangdong, China; Division of Emerging Interdisciplinary Areas, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China. Electronic address:
Background: The longitudinal association between infectious diseases and the risk of type 2 diabetes (T2D) remains unclear.
Methods: Based on the UK Biobank, the prospective cohort study included a total of 396,080 participants without diabetes at baseline. We determined the types and sites of infectious diseases and incident T2D using the International Classification of Diseases 10th Revision codes (ICD-10).
Hospital-treated infectious diseases, infection burden and risk of Parkinson disease: An observational and Mendelian randomization study.
Brain Behav Immun
August 2024
Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, Guangdong, China; Division of Emerging Interdisciplinary Areas, Center for Aging Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. Electronic address:
Article Synopsis
- - The study investigates the link between infections and the development of Parkinson's disease (PD), finding that hospital-treated infections increase PD risk, notably from neurological and lower respiratory infections.
- - Data from the UK Biobank were used to assess the impact of infection burden over time and specific types of infections on PD incidence, revealing a dose-response relationship with increasing infection episodes correlating with higher PD risk.
- - Both observational and genetic analyses suggest a causal link between infections and PD, highlighting the need for further research in this area.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!