Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/s-0044-1787745 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unusual co-occurrence of hypertrophic inferior olivary degeneration with infratentorial cavernomatosis and orbital cavernous hemangioma.
Radiol Case Rep
January 2025
Radiology Department, Mohammed Vth military hospital, 10010 Rabat, Morocco.
Article Synopsis
- * Cavernomas and orbital cavernous hemangiomas are specific types of vascular malformations linked to HOD, but their combination is extremely rare, with only one previous case reported.
- * A notable case involved a 26-year-old male with eye bulging and myoclonus, where MRI revealed HOD from cavernous malformations, highlighting the need to consider vascular issues as potential causes of HOD.
Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1.
Hum Mol Genet
December 2024
Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, 6124 Harry Hines Blvd. Dallas, TX 75390, United States.
Article Synopsis
- The inferior olive (IO) is a key brainstem region affected by spinocerebellar ataxias (SCAs), impacting motor learning, but its degeneration mechanisms remain unclear.
- Researchers studied SCA1 using a genetically modified mouse model (SCA1-KI) and found that these mice show olivary hypertrophy similar to hypertrophic olivary degeneration (HOD), with early neuronal changes but no loss of cells.
- The SCA1-KI IO neurons are hyperexcitable and have reduced expression of ion channels that typically regulate their activity, indicating a dysregulation linked to mutant ataxin-1 expression in these neurons.
Genetic and pathophysiological insights from autopsied patient with primary familial brain calcification: novel MYORG variants and astrocytic implications.
Acta Neuropathol Commun
August 2024
Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Primary familial brain calcification (PFBC) is a genetic neurological disorder characterized by symmetric brain calcifications that manifest with variable neurological symptoms. This study aimed to explore the genetic basis of PFBC and elucidate the underlying pathophysiological mechanisms. Six patients from four pedigrees with brain calcification were enrolled.
View Article and Find Full Text PDFPostoperative brainstem cavernous malformations complicated with LGI1 encephalitis and hypertrophic olivary degeneration: A case report and literature review.
Clin Neurol Neurosurg
September 2024
Institute of Neurology, Anhui University of Chinese Medicine, Hefei, Anhui Province, China; Wannan Medical College, Wuhu, Anhui Province, China. Electronic address:
Article Synopsis
- - A 34-year-old male underwent surgery for brainstem cavernous malformations after experiencing repeated dizziness and headaches due to recurrent bleeding.
- - One month post-surgery, he displayed unusual mental behavior and was diagnosed with LGI1 encephalitis, a condition linked to autoimmune issues affecting the brain.
- - Six months later, imaging revealed hypertrophic olivary degeneration (HOD), highlighting the complexity and rarity of this clinical case involving post-operative complications.
Olivary Hypertrophy Induced Palatal Myoclonus in a Treated Case of Medulloblastoma.
Neuropediatrics
December 2024
Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Bathinda, Punjab, India.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!