AI Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease is a major cause of chronic liver issues globally, and regular physical activity is recommended as an effective treatment.
- A 16-week randomized controlled trial with 45 adults will explore the effects of different exercise doses on various health outcomes related to this liver condition.
- The study aims to clarify how exercise influences liver fat (measured by MRI), inflammation, and overall quality of life, making it the first to compare varying exercise intensities in this context.
Article Abstract
Recently renamed, metabolic dysfunction-associated steatotic liver disease remains a leading cause of chronic liver disease worldwide. Regular physical activity is recommended as a treatment for all with this condition because it is highly efficacious, especially when exercise training is undertaken with a specific goal in mind. Despite decades of research demonstrating exercise's efficacy, key questions remain about the mechanism of benefit and most efficacious dose, as well as the independent impact on liver histology. To answer these questions, we present the design of a 16-week randomized controlled clinical trial of 45 adults aged 18-69 years with metabolic dysfunction-associated steatohepatitis. The primary aim of this study is to better understand the dose required and mechanisms to explain how exercise impacts multiple clinical end points in metabolic dysfunction-associated steatohepatitis. The primary outcome is MRI-measured liver fat. Secondary outcomes include other biomarkers of liver fibroinflammation, liver histology, and mechanistic pathways, as well as cardiometabolic risk and quality of life. This is the first study to compare different doses of exercise training to determine if there is a differential impact on imaging and serum biomarkers as well as liver histology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11186820 | PMC |
| http://dx.doi.org/10.1097/HC9.0000000000000464 | DOI Listing |
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