Monocarbonyl analogs of curcumin (MACs) represent structurally modified versions of curcumin. The existing literature indicates that MACs exhibit enhanced anticancer properties compared with curcumin. Numerous research articles in recent years have emphasized the significance of MACs as effective anticancer agents. This review focuses on the latest advances in the anticancer potential of MACs, from 2014 to 2024, including discussions on their mechanism of action, structure-activity relationship (SAR), and in silico molecular docking studies.
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Pyatigorsk Medical and Pharmaceutical Institute - a branch of Volgograd State Medical University, Volgograd, Russia.
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Dalton Trans
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Department of Chemistry, University of Georgia, Athens, Georgia, 30602, USA.
The structures and energetics of the binuclear methylphosphinidene complexes of cyclopentadienylruthenium carbonyls of the type [MePRu(CO)Cp] ( = 4, 3, 2, 1) have been investigated for comparison with their previously studied iron analogues. For the tetracarbonyls and tricarbonyls [MePM(CO)Cp] ( = 4, 3) substituting ruthenium for iron has relatively little effect on the energetically preferred structures. Thus such structures have two-electron donor bridging MeP groups with no metal-metal bond for the tetracarbonyls and a metal-metal single bond for the tricarbonyls.
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Article Synopsis
- The study investigates the role of the MD-2-TLR4 signaling pathway in cognitive decline related to obesity in male Wistar rats.
- Researchers used two MD-2 inhibitors, MAC28 and 2i-10, to explore their effects on cognitive impairment associated with a high-fat diet over 16 weeks.
- Blocking the MD-2-TLR4 pathway in obese rats improved cognitive function by reducing brain inflammation and damage, suggesting that targeting MD-2 could be a promising strategy for treating obesity-related cognitive decline.
Impact of monocarbonyl analogs of curcumin (MACs) C66 and B2BrBC on the expression of diabetes-associated genes in streptozotocin-treated rat pancreatic RIN-m cells-Quantitative RT-PCR array data.
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This paper presents a dataset obtained from an RT-qPCR array analysis of rat pancreatic RIN-m cells treated with two monocarbonyl analogs of curcumin (MACs), C66 and B2BrBC in the presence or absence of streptozotocin (STZ). The array quantified the expression of 84 genes associated with the onset, development, and progression of diabetes. This dataset provides information on the gene expression profiles of pancreatic cells modulated by two specific MACs in a diabetic context.
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