To analyze the etiology, diagnosis, and treatment of unexplained conductive hearing loss (UCHL) with intact tympanic membrane. A systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 642 articles were retrieved from databases such as PubMed, Embase, Web of Science, and Cochrane. Fifty-four research articles and 21 case reports were screened out according to the inclusion and exclusion criteria for analysis of the etiology of UCHL. Seven research articles with UCHL who underwent exploratory tympanotomy were selected for data extraction and analysis of clinical characteristics. UCHL is a common manifestation of various diseases, including congenital ossicular anomalies (COA), otosclerosis (OTS), congenital middle ear cholesteatoma (CMEC), oval window atresia, superior semicircular-canal dehiscence, congenital stapedial footplate fixation, middle ear osteoma or adenoma, congenital ossification of stapedial tendon, and so on. A total of 522 patients were included in the 7 articles; among whom OTS showed a tendency to increase with age. The main symptoms were hearing loss, followed by tinnitus, dizziness, ear fullness, ear pain, facial paralysis. A total of 87.5% to 93.0% patients with COA manifested as nonprogressive deafness that occurred since childhood, with tinnitus incidence of 15.6% to 30.2%, and 86.4% to 96.4% patients with OTS presented with progressive hearing loss, with tinnitus incidence of 60.1% to 90.9%. The diagnosis positive rate of high-resolution computed tomography (HRCT) was 33.8% to 87.1%, and CMEC was higher than that of COA (83.3%-100% vs 28.6%-64%). All the articles reported good hearing recovery. The most common surgical complications included taste abnormalities, tinnitus, and dizziness. UCHL presents with similar clinical manifestations and poses challenges in preoperative diagnosis. Exploratory tympanotomy is the primary method for diagnosis and treatment, with good prognosis after removing the lesion and reconstructing hearing during the operation. Children can also safely undergo the surgery.
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http://dx.doi.org/10.1177/01455613241262129 | DOI Listing |
Int J Pediatr Otorhinolaryngol
December 2024
Department of Audiology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Electronic address:
Background: Auditory attention is an important cognitive factor that significantly affects speech perception in noisy environments. Hearing loss can impact attention, and it can impair speech perception in noise. Auditory attention training improves speech perception in noise in children with hearing loss.
View Article and Find Full Text PDFNeurosci Biobehav Rev
December 2024
Cambridge Hearing Group, Department of Psychology, University of Cambridge, Cambridge, United Kingdom; Vision and Eye Research Institute, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Cambridge, United Kingdom. Electronic address:
Blindness or deafness can significantly influence sensory abilities in intact modalities, affecting communication, orientation and navigation. Explanations for why certain abilities are enhanced and others degraded include: crossmodal cortical reorganization enhances abilities by providing additional neural processing resources; and sensory processing is impaired for tasks where calibration from the normally intact sense is required for good performance. However, these explanations are often specific to tasks or modalities, not accounting for why task-dependent enhancement or degradation are observed.
View Article and Find Full Text PDFOtolaryngol Head Neck Surg
December 2024
Department of Otorhinolaryngology, Gazi University Faculty of Medicine, Ankara, Turkey.
Objective: This study aimed to attenuate cochlear inflammation following noise-induced hearing loss by targeting IL-1. We evaluated the effectiveness of IL-1 inhibition through auditory and histological assessments in an animal model.
Study Design: Experimental animal study.
Biomed Pharmacother
December 2024
Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea; School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address:
mPTP is a multi-protein complex that opens in mitochondria during cell death. Cisplatin-induced hearing loss is also known to be caused by mPTP opening. Thus, our study evaluated the protective effect of a novel mPTP inhibitor named DBP-iPT against cisplatin-induced hearing loss.
View Article and Find Full Text PDFQ J Exp Psychol (Hove)
December 2024
Toronto Metropolitan University, Department of Psychology.
Even with the use of hearing aids (HAs), speech in noise perception remains challenging for older adults, impacting communication and quality of life outcomes. The association between music perception and speech-in-noise (SIN) outcomes is of interest, as there is evidence that professionally trained musicians are adept listeners in noisy environments. Thus, this study explored the association between music processing, cognitive factors, and the outcome variable of SIN perception, in older adults with hearing loss.
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