AI Article Synopsis
- Scientists studied the placenta during pregnancy, which helps the mother's body accept the baby as part of it.
- They created special lab-grown structures called organoids to learn more about the different types of cells (trophoblasts) in the placenta and how they affect the mother's immune system.
- The researchers found that each type of trophoblast influences immune cells in different ways, and growing these cells in 3D helps them understand this better than when grown flat in 2D.
Article Abstract
During pregnancy, the human placenta establishes tolerance toward fetal allogeneic tissue, where specialized trophoblast subtypes play a complex role in local and peripheral immunomodulation. However, due to inadequate models to study the early gestation of the human placenta, each trophoblast subtype's role in modulating the maternal immune response has remained elusive. Here, we derived human placental organoids from early gestation trophoblast stem cells to (1) identify patterns of immunomodulatory protein expression by trophoblast subtype and (2) evaluate the effects of the placental organoid secretome on immune cell activation and regulation. We show that the three primary trophoblast phenotypes had distinct influences on immune cell phenotype and activation and that three-dimensional culture significantly alters trophoblast immunomodulation relative to traditional two-dimensional trophoblast culture.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11185637 | PMC |
| http://dx.doi.org/10.1101/2024.06.05.597501 | DOI Listing |
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