Lysosomal Degradation of Extracellular Targets: Innovations and Implications.

ACS Med Chem Lett

Usona Institute, Fitchburg, Wisconsin 53711-5300, United States.

Published: June 2024

The therapeutic landscape is experiencing a significant transformation with the development of strategies focused on the lysosomal degradation of extracellular targets. This innovative approach holds promise for combating many diseases by targeting and degrading pathogenic extracellular molecules. Pioneering advancements in this field introduce the concept of utilizing bifunctional compounds for the selective degradation of extracellular proteins and molecules. This Patent Highlight delves into the scientific principles, technological innovations, and therapeutic potential of these strategies, emphasizing their critical role in reshaping the future of medical treatments and highlighting their potential impact across a diverse range of disease contexts.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11181507PMC
http://dx.doi.org/10.1021/acsmedchemlett.4c00180DOI Listing

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