AI Article Synopsis
- Beta-thalassemia major patients often experience endocrinopathies, and a study was conducted to explore how demographic factors and blood transfusions relate to these conditions.
- The study included 114 patients aged 3-38, mostly children, and analyzed various hormonal and biochemical blood markers alongside bone mineral density (BMD) assessments.
- Findings revealed age as a key factor influencing risk for complications like short stature, diabetes, and low BMD, indicating the need for early monitoring in patients as they enter late childhood and early adolescence.
Article Abstract
Background: Beta-thalassemia major patients frequently have endocrinopathies. We tried to determine relation between demographic and transfusion factor and endocrinopathies.
Methods: Major beta-thalassemia patients (n=114 cases), 3-38 yr of age, entered this study. Female to male ratio was 51/63. Children (less than 20 yr) formed 57% of participants. Information about bone mineral density (BMD) and hormonal and biochemistry blood evaluation including fasting blood sugar (FBS), ferritin, triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH), testosterone (males), and estradiol (females) entered data sheet.
Results: Sex and ferritin level showed no significant correlation with above disorders. Age significantly correlated to short stature, diabetes, low BMD at femur and neck (, 0.031, 0.008, 0.009 and <0.001, respectively) . The risk of short stature had increased in 12 yr and older patients 7.71 times than younger patients (= 0.008). The risk of diabetes had increased in 35 yr and older patients 26.25 times than younger patients (= 0.03). The risk of Z-score ≤ -2 in femoral region has increased in 19 yr and older patients 5.84 times than younger patients (= 0.002). The risk of Z-score ≤ -2 in spinal region has increased in 14 yr and older patients 17 times than younger patients (= 0.007).
Conclusion: The main factor related with endocrinopathies was age. The correlation between age and short stature, diabetes and low BMD was positive. Therefore, we recommend early monitoring of thalassemia patients (in their late childhood and early teenage) for these complications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11182464 | PMC |
| http://dx.doi.org/10.18502/ijph.v53i2.14928 | DOI Listing |
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