AI Article Synopsis
- Tuberculosis (TB) continues to be a major global health threat, and the BCG vaccine shows inconsistent effectiveness in adults due to immune function issues.
- Macrophage mannose receptor (MR) plays a key role in enhancing the immune response to TB by improving antigen processing and presentation, but its specific functions during BCG vaccination are not yet fully understood.
- Research indicates that a lack of MR in macrophages weakens the immune response to BCG, highlighting its importance in vaccine efficacy and suggesting directions for improving TB prevention strategies.
Article Abstract
Tuberculosis (TB), caused by ( . ), remains one of the leading causes of fatal infectious diseases worldwide. The only licensed vaccine, Bacillus Calmette-Guérin (BCG), has variable efficacy against TB in adults. Insufficiency of immune cell function diminishes the protective effects of the BCG vaccine. It is critical to clarify the mechanism underlying the antimycobacterial immune response during BCG vaccination. Macrophage mannose receptor (MR) is important for enhancing the uptake and processing of glycoconjugated antigens from pathogens for presentation to T cells, but the roles of macrophage MR in the BCG-induced immune response against . are not yet clear. Here, we discover that macrophage MR deficiency impairs the antimycobacterial immune response in BCG-vaccinated mice. Mechanistically, macrophage MR triggers JAK-STAT1 signaling, which promotes antigen presentation via upregulated MHC-II and induces IL-12 production by macrophages, contributing to CD4 T cell activation and IFN-γ production. MR deficiency in macrophages reduces the vaccine efficacy of BCG and increases susceptibility to . H37Ra challenge in mice. Our results suggest that MR is critical for macrophage antigen presentation and the antimycobacterial immune response to BCG vaccination and offer valuable guidance for the preventive strategy of BCG immunization.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11399420 | PMC |
| http://dx.doi.org/10.3724/abbs.2024100 | DOI Listing |
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