A pH-Responsive Polycaprolactone-Copper Peroxide Composite Coating Fabricated via Suspension Flame Spraying for Antimicrobial Applications.

In this study, a pH-responsive polycaprolactone (PCL)-copper peroxide (CuO) composite antibacterial coating was developed by suspension flame spraying. The successful synthesis of CuO nanoparticles and fabrication of the PCL-CuO composite coatings were confirmed by microstructural and chemical analysis. The composite coatings were structurally homogeneous, with the chemical properties of PCL well maintained. The acidic environment was found to effectively accelerate the dissociation of CuO, allowing the simultaneous release of Cu and HO. Antimicrobial tests clearly revealed the enhanced antibacterial properties of the PCL-CuO composite coating against both and under acidic conditions, with a bactericidal effect of over 99.99%. This study presents a promising approach for constructing pH-responsive antimicrobial coatings for biomedical applications.