Protocell models play a pivotal role in the exploration of the origin of life. Vesicles are one type of protocell model that have attracted much attention. Simple single-chain amphiphiles (SACs) and organic small molecules (OSMs) possess primitive relevance and were most likely the building blocks of protocells on the early Earth. OSM@SAC vesicles have been considered to be plausible protocell models. Pyrite (FeS), a mineral with primitive relevance, is ubiquitous in nature and plays a crucial role in the exploration of the origin of life in the mineral-water interface scenario. "How do protocell models based on OSM@SAC vesicles interact with a mineral-water interface scenario that simulates a primitive Earth environment" remains an unresolved question. Hence, we select primitive relevant sodium monododecyl phosphate (SDP), isopentenol (IPN) and pyrite (FeS) mineral particles to build a protocell model. The model investigates the basic physical and chemical properties of FeS particles and reveals the effects of the size, content and duration of interaction of FeS particles on IPN@SDP vesicles. This deepens the understanding of protocell growth mechanisms in scenarios of mineral-water interfaces in primitive Earth environments and provides new information for the exploration of the origin of life.
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http://dx.doi.org/10.3390/molecules29112664 | DOI Listing |
Front Immunol
January 2025
Central Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
In recent years, tumors have emerged as a major global health threat. An increasing number of studies indicate that the production, development, metastasis, and elimination of tumor cells are closely related to the tumor microenvironment (TME). Advances in artificial intelligence (AI) algorithms, particularly in large language models, have rapidly propelled research in the medical field.
View Article and Find Full Text PDFSmall
January 2025
Department of Chemistry, Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, P. R. China.
Ulcerative colitis (UC) involves persistent inflammation in the colon and rectum, with excessive reactive oxygen species (ROS) accumulation. This ROS buildup damages colonic epithelial cells and disrupts intestinal flora, worsening disease progression. Current antioxidant therapies are limited due to their instability in the gut and lack of targeting, hindering precise intervention at the lesion site.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Department of Stomatology, People's Hospital of Xinjiang Autonomous Region, Urumqi City, China.
Background: The progression and severity of periodontitis (PD) are associated with the release of extracellular vesicles by periodontal tissue cells. However, the precise mechanisms through which exosome-related genes (ERGs) influence PD remain unclear. This study aimed to investigate the role and potential mechanisms of key exosome-related genes in PD using transcriptome profiling at the single-cell level.
View Article and Find Full Text PDFCurr Med Imaging
January 2025
Xi'an Institute of Optics and Precision Mechanics of CAS, No.17, Information Avenue, New Industrial Park, Gaoxin District, Xi 'an, China.
Background: Cervical cancer is a prevalent malignancy among women, often asymptomatic in early stages, complicating detection.
Objective: This study aims to investigate innovative techniques for early cervical cancer detection using a novel U-RCNNS model.
Methods: Cervical epithelial cell images stained with hematoxylin and eosin (HE) were analyzed using the U-RCNNS model, which integrates U-Net for segmentation and R-CNN for object detection, incorporating dilated convolution techniques.
J Nutr Sci Vitaminol (Tokyo)
January 2025
Key Laboratory of Sichuan Cuisine Artificial Intelligence, Sichuan Tourism University.
This study aimed to investigate the regulatory effects of raspberry ketone on hypothalamic inflammation and its mechanism. Mouse microglia cells (BV2 cells) were cultured in vitro with palmitic acid (100 μM) to induce inflammation model and then incubated with raspberry ketone (5, 20, 50 μM) alone or raspberry ketone (50 μM) and the specific inhibitor of uncoupling protein 2 (UCP2), genipin (10 μM), to test the role of UCP2 in raspberry ketone regulatory of inflammation. Meanwhile, C57BL/6J mice were fed a high-fat diet containing raspberry ketone (0.
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