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Three New Ionone Glycosides from Maxim. | LitMetric

Three New Ionone Glycosides from Maxim.

Molecules

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.

Published: May 2024

Six ionone glycosides (- and -), including three new ones, named capitsesqsides A-C (-), together with an eudesmane sesquiterpenoid glycoside () and three known triterpenoid saponins (-) were isolated from . The structures of these compounds were determined by extensive spectroscopic techniques (MS, UV, 1D-NMR, and 2D-NMR) and comparison with data reported in the literature. The absolute configurations were determined by comparison of the experimental and theoretically calculated ECD curves and LC-MS analyses after acid hydrolysis and derivatization. The anti-inflammatory activities of these compounds were evaluated in the LPS-induced RAW264.7 cells. Molecular docking demonstrated that has a favorable affinity for NLRP3 and iNOS.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11173609PMC
http://dx.doi.org/10.3390/molecules29112462DOI Listing

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