: The aim of this study was to establish a histologic baseline for cryoanalgesia of 2 min duration and evaluate the effects of different freeze durations. : A porcine model was used in which the application of bilateral cryoanalgesia from intercostal spaces T3-T7 was completed via partial median sternotomy. The animals were kept alive for 7 days and the ribcages were sent to a specialized center for histopathologic analysis of the freezing injury. : Forty freezing lesions were completed and analyzed histologically. Thirty-eight (95%) of the cryo-lesions presented 100% nerve fiber degeneration at or distal to the ablation site, with preservation of the perineural connective tissue, as intended. The two unaffected nerves were found to be physically located outside of the freezing area. : The complete axonal degeneration with preservation of the perineural tissue opens the possibility to shorter freezing times than the recommended 2 min. Visualization of the nerve and positioning of the probe is important in ensuring the proper effect on the nerve. This histologic analysis confirms the process triggered by cryoanalgesia that, until now, had only been assumed.
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| http://dx.doi.org/10.3390/jcm13113304 | DOI Listing |
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Article Synopsis
- A defect in the sternum and ribs can lead to a funnel-shaped chest wall, and the Nuss procedure is a minimally invasive surgical correction that can cause significant pain and sensory issues.
- Combining cryoanalgesia with standard pain management improves surgical outcomes, with this study examining if reducing cryo-application time from two minutes to one minute affects pain perception and sensory disturbances.
- The study involved 33 patients and found no significant differences in pain severity or sensory disturbances between the one-minute and two-minute cryo-application methods, suggesting that one minute is just as safe and effective as the traditional approach.
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