AI Article Synopsis
- N-methylpyridinium (NMP) is created during coffee roasting from trigonelline and has potential health benefits due to its antioxidant properties.
- Preliminary studies have shown that NMP may protect against LPS-induced neuroinflammation in human glioblastoma cells by reducing pro-inflammatory cytokines and inhibiting the NF-κB signaling pathway.
- This research suggests that drinking coffee, which contains NMP, could help protect against neuroinflammatory issues relevant to neurological disorders.
Article Abstract
N-methylpyridinium (NMP) is produced through the pyrolysis of trigonelline during the coffee bean roasting process. Preliminary studies suggest that NMP may have health benefits, thanks to its antioxidant properties. Based on this background, the aim of this study was to evaluate whether NMP could have a protective effect against LPS-induced neuroinflammation in human glioblastoma cells (U87MG). With this aim, U87MG cells were pre-treated with NMP (0.5 μM) for 1 h and then exposed to LPS (1 μg/mL) for 24 h. Our findings show that NMP attenuates LPS-induced neuroinflammation by reducing the expression of pro-inflammatory cytokines, such as IL-1β, TNF-α and IL-6, through the inhibition of the NF-κB signaling pathway, which is critical in regulating inflammatory responses. NMP is able to suppress the activation of the NF-κB signaling pathway, suggesting its potential in preventing neuroinflammatory conditions. These outcomes support the notion that regular consumption of NMP, possibly through coffee consumption, may offer protection against neuroinflammatory states implicated in neurological disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172780 | PMC |
| http://dx.doi.org/10.3390/ijms25116000 | DOI Listing |
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