AI Article Synopsis
- There was a study to see if a drug called MaxiPost could cause migraine-like headaches in people who have persistent headaches after a brain injury.
- The study involved 21 adults with these headaches, and they received either the drug or a placebo (a fake treatment that doesn't do anything) during two separate sessions.
- Results showed that more people developed migraine-like headaches after taking MaxiPost compared to the placebo, suggesting that this drug opens certain channels in the brain that might trigger headaches.
Article Abstract
Background: Large conductance calcium-activated potassium (BK) channels have been implicated in the neurobiological underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-traumatic headache (PPTH), we aimed to examine whether MaxiPost (a BK channel opener) could induce migraine-like headache in persons with PPTH.
Methods: This is a randomized double-blind, placebo-controlled, two-way crossover study from September 2023 to December 2023. Eligible participants were adults with PPTH after mild traumatic brain injury who reported having no personal history of migraine. The randomized participants received a single dose of either MaxiPost (0.05 mg/min) or placebo (isotonic saline) that was infused intravenously over 20 minutes. The two experiment sessions were scheduled at least one week apart to avoid potential carryover effects. The primary endpoint was the induction of migraine-like headache after MaxiPost as compared to placebo within 12 hours of drug administration. The secondary endpoint was the area under the curve (AUC) values for headache intensity scores between MaxiPost and placebo over the same 12-hour observation period.
Results: Twenty-one adult participants (comprising 14 females and 7 males) with PPTH were enrolled and completed both experiment sessions. The proportion of participants who developed migraine-like headache was 11 (52%) of 21 participants after MaxiPost infusion, in contrast to four (19%) participants following placebo (P = .02). Furthermore, the median headache intensity scores, represented by AUC values, were higher following MaxiPost than after placebo (P < .001).
Conclusions: Our results indicate that BK channel opening can elicit migraine-like headache in persons with PPTH. Thus, pharmacologic blockade of BK channels might present a novel avenue for drug discovery. Additional investigations are nonetheless needed to confirm these insights and explore the therapeutic prospects of BK channel blockers in managing PPTH.
Gov Identifier: NCT05378074.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11186171 | PMC |
| http://dx.doi.org/10.1186/s10194-024-01808-0 | DOI Listing |
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