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Generation Victoria (GenV): protocol for a longitudinal birth cohort of Victorian children and their parents.
BMC Public Health
January 2025
Murdoch Children's Research Institute, 50 Flemington Road, Parkville, VIC, 3052, Australia.
Background: In a world confronted with new and connected challenges, novel strategies are needed to help children and adults achieve their full potential, to predict, prevent and treat disease, and to achieve equity in services and outcomes. Australia's Generation Victoria (GenV) cohorts are designed for multi-pronged discovery (what could improve outcomes?) and intervention research (what actually works, how much and for whom?). Here, we describe the key features of its protocol.
View Article and Find Full Text PDFIntroduction: The St. Göran Bipolar Project (SBP) is a longitudinal outpatient study investigation aimed at identifying predictive factors associated with long-term outcomes in individuals with bipolar disorder. These outcomes include cognitive function, relapse rate, treatment responses, and functional outcomes.
View Article and Find Full Text PDFCharacterization of an Ecdysone Oxidase from (L.) and Its Role in Bt Cry1Ac Resistance.
J Agric Food Chem
January 2025
State Key Laboratory of Vegetable Biobreeding, Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Understanding the molecular mechanisms underlying insect resistance to (Bt) pesticidal proteins is crucial for sustainable pest management. Here, we found that downregulation of the ecdysone oxidase gene () in the normal feeding stages contributes to increased 20-hydroxyecdysone (20E) titer and mediates resistance to the Bt Cry1Ac toxin. The gene was cloned and its expression was significantly downregulated in the midgut of Bt-resistant and Cry1Ac-selected .
View Article and Find Full Text PDFPaving the way for Alzheimer's disease blood-based biomarkers in primary care.
Alzheimers Dement
December 2024
Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Blood-based biomarkers (BBBMs) for Alzheimer's disease (AD) have the potential to revolutionize the detection and management of cognitive impairment. AD BBBMs are not currently recommended for use in primary care but may soon be as research demonstrates their clinical utility for differential diagnosis and patient management. To prepare for the incorporation of AD BBBMs into primary care, several practical challenges must be addressed.
View Article and Find Full Text PDFToward Alleviating the Stigma of Hearing Aids: A Review.
Audiol Res
December 2024
Starkey Hearing, Eden Prairie, MN 55344, USA.
Despite the significant advancements in hearing aid technology, their adoption rates remain low, with stigma continuing to be a major barrier for many. This review aims to assess the origins and current state of hearing aid stigma, as well as explore potential strategies for alleviating it. This review examines the societal perceptions, psychological impacts, and recent technological advancements that can influence hearing aid adoption and reduce stigma.
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