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| http://dx.doi.org/10.1098/rspb.2024.1198 | DOI Listing |
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Metabolic acidosis with elevated anion gap and euglycemic ketoacidosis in pregnant and postpartum women with severe Covid-19.
Ann Med
December 2025
Intensive Care Unit, State Institute for Infectious Diseases São Sebastião, Rio de Janeiro, Rio de Janeiro, Brazil.
Background/objectives: Pregnant and postpartum women have a higher risk for developing severe Covid-19 and other clinical and obstetric complications. This study aims to evaluate the frequency of metabolic acidosis with elevated anion gap and describe a case series of euglycemic ketoacidosis (EKA) in pregnant and postpartum women with severe confirmed or suspected Covid-19.
Materials And Methods: Observational retrospective study carried in a reference intensive care unit from May 2020 to June 2022.
Exploring Hypoglycemic Ketoacidosis in Nondiabetic Patients on Tirzepatide: Is Starvation the Culprit?
Am J Case Rep
December 2024
Department of Internal Medicine, Ahmadi Hospital, Ahmadi, Kuwait.
BACKGROUND Tirzepatide is a long-acting glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist administered via subcutaneous injection for weight reduction and treating type 2 diabetes. CASE REPORT We report case series of hypoglycemic ketoacidosis after the use of tirzepatide to treat nondiabetic patients with obesity from Kuwait. The first case was a 29-year-old woman with a body mass index (BMI) of 32 kg/m² who developed abdominal pain and vomiting after increasing the dose to 5 mg subcutaneously in week 5 of treatment.
View Article and Find Full Text PDFTranscriptional memory drives accelerated re-activation of several biosynthetic gene clusters in Aspergillus nidulans.
Microbiol Res
February 2025
Institute of Microbial Genetics, Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna (BOKU), Tulln a.d. Donau 3430, Austria; Research Platform Bioactive Microbial Metabolites (BiMM), Konrad Lorenz Strasse 24, Tulln a.d. Donau 3430, Austria. Electronic address:
Organisms are repeatedly exposed to fluctuating environmental and nutritional conditions. Transcriptional memory has been shown to be a mechanism to cope with these fluctuations because it increases the speed and the magnitude of the cellular response to a certain re-occurring condition and therefore optimizes adaptation and fitness in a given environment. We found that genes coding for sterigmatocystin (ST) production in Aspergillus nidulans are activated stronger when cells are repeatedly exposed to nutrient starvation, compared to cells that experience this condition for the first time.
View Article and Find Full Text PDFOutcomes After Duodenoduodenostomy for Superior Mesenteric Artery Syndrome.
Am Surg
November 2024
Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Background: Superior Mesenteric Artery Syndrome (SMAS) is a very rare disease that causes starvation and malnutrition secondary to a mechanical obstruction of the 3 portion of the duodenum between the superior mesenteric artery and aorta. Long-term outcomes following surgery for SMAS by current methods have a high failure rate of 21%-67%. We report the 3-year outcomes of a novel operation for SMAS described as the duodenoduodenostomy (DD).
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