AI Article Synopsis
- Recent research on nerve regeneration has focused on understanding the mechanisms involved and improving surgical techniques, with rats being the primary animal model used due to their practicality and reliability.
- This article reviews various rat models specifically for cranial nerve research, detailing the methods for achieving proper surgical exposure.
- The findings highlight the technical aspects, applications, and pros and cons of each model, emphasizing the diverse surgical techniques applied in studying cranial nerve injuries in rats.
Article Abstract
Background: The intricacies of nerve regeneration following injury have prompted increased research efforts in recent years, with a primary focus on elucidating regeneration mechanisms and exploring various surgical techniques. While many experimental animals have been used for these investigations, the rat continues to remain the most widely used model due to its cost-effectiveness, accessibility, and resilience against diseases and surgical/anesthetic complications. A comprehensive evaluation of all the experimental rat models available in this context is currently lacking.
Methods: We summarize rat models of cranial nerves while furnishing descriptions of the intricacies of achieving optimal exposure.
Results: This review article provides an examination of the technical exposure, potential applications, and the advantages and disadvantages inherent to each cranial nerve model.
Conclusion: Specifically in the context of cranial nerve injury, numerous studies have utilized different surgical techniques to expose and investigate the cranial nerves in the rat.
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| http://dx.doi.org/10.1055/s-0044-1787729 | DOI Listing |
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