The study was aimed to formulate and evaluate apremilast-loaded zinc oxide-mesoporous silica nanoparticles for treatment of psoriasis. Mesoporous silica nanoparticles were prepared by using sol-gel method and evaluated for particle size, drug release, cytotoxicity study and pharmacodynamic study. The synthesized mesoporous silica nanoparticles showed particle size of 319.9 ± 3.9 nm, with 24 ± 0.217% of loading capacity. cytotoxicity study on A-431 cell line showed increased anti-psoriatic activity of apremilast-loaded zinc oxide-mesoporous silica nanoparticles. pharmacodynamic study and histological studies showed improved efficacy of drug in imiquimod-induced psoriasis mice model. The apremilast-loaded zinc oxide-mesoporous silica nanoparticles showed improved therapeutic efficacy, suggesting that they are promising approach for topical treatment of psoriasis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285223 | PMC |
| http://dx.doi.org/10.1080/20415990.2024.2343646 | DOI Listing |
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