We have developed an operationally simple method for the synthesis of dialkyl α-bromoketones from bromoalkenes by utilizing a hypervalent iodine-catalyzed oxidative hydrolysis reaction. This catalytic process provides both symmetrical and unsymmetrical dialkyl bromoketones with moderate yields across a broad range of bromoalkene substrates. Our studies also reveal the formation of Ritter-type side products by an alternative reaction pathway.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11181184 | PMC |
| http://dx.doi.org/10.3762/bjoc.20.111 | DOI Listing |
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