Objectives: To develop a statistical approach that provides a quantitative index measuring the magnitude of the irregularity of the breathing response to exercise for the diagnosis of dysfunctional breathing.
Design: Cross-sectional, retrospective, real-world study.
Setting: Single-centre study.
Participants: A population of 209 patients investigated with cardiopulmonary exercise testing in our institution for unexplained or disproportionate exertional dyspnoea between January and July 2022.
Primary And Secondary Outcome Measures: A novel statistical approach providing a quantitative index-proportional tidal volume variation (PTVV)-was developed to measure the magnitude of the irregularity of the breathing response to exercise.
Results: PTVV provided a reliable statistical readout for the objective assessment of DB with a prediction accuracy of 78% (95% CI: 72 to 83%). The prevalence of DB in the investigated population was high with more than half of the patients affected by moderate-to-severe DB.
Conclusions: PTVV can easily be implemented in the clinical routine. Our study suggests a possible further simplification for the diagnosis of DB with two objective criteria including PTVV and one single criterion for hyperventilation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11184190 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2023-083401 | DOI Listing |
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