AI Article Synopsis
- - The review highlights how eosinophils and airway epithelial cells interact in asthma, showing that eosinophils can influence epithelial cell functions and vice versa.
- - It discusses the impact of eosinophil products, like granule proteins, on airway cells and the various mediators released by epithelial cells that affect eosinophil behavior.
- - The key takeaway is that these interactions can produce both harmful and helpful effects in the context of asthma, pointing to a complex signaling relationship between these cell types.
Article Abstract
Background: Eosinophils have numerous roles in type 2 inflammation depending on their activation states in the blood and airway or after encounter with inflammatory mediators. Airway epithelial cells have a sentinel role in the lung and, by instructing eosinophils, likely have a foundational role in asthma pathogenesis.
Summary: In this review, we discuss various topics related to eosinophil-epithelial cell interactions in asthma, including the influence of eosinophils and eosinophil products, e.g., granule proteins, on epithelial cell function, expression, secretion, and plasticity; the effects of epithelial released factors, including oxylipins, cytokines, and other mediators on eosinophils, e.g., on their activation, expression, and survival; possible mechanisms of eosinophil-epithelial cell adhesion; and the role of intra-epithelial eosinophils in asthma.
Key Messages: We suggest that eosinophils and their products can have both injurious and beneficial effects on airway epithelial cells in asthma and that there are bidirectional interactions and signaling between eosinophils and airway epithelial cells in asthma.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534548 | PMC |
| http://dx.doi.org/10.1159/000539309 | DOI Listing |
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