AI Article Synopsis
- Epilepsy is a common brain problem in kids that causes frequent seizures, which can harm their bodies and minds, affecting their growth and health.
- New studies show that kids with epilepsy have different types and amounts of gut microbes compared to healthy kids, which could play a role in their seizures.
- The review looks at how these gut microbes and what they produce might affect seizures and explores connections between gut health and brain activity.
Article Abstract
Epilepsy a prevalent childhood neurological disorder, arises from chronic brain dysfunction caused by oversynchronized firing of neurons. Frequent seizures often lead to both physical and intellectual damage in children, seriously affecting their growth and development, life and health. Recent research studies have shown that the intestinal microbes in pediatric epilepsy is significantly different from that of healthy children, characterised by changes in the abundance of specific microbe communities and a reduction in diversity. These alterations may influence epileptic seizures through various pathways, including the microbiota-gut-brain axis by modulating neurotransmitters metabolism, affecting gut barrier function and immune responses, and directly impacting brain activity via the vagus nerves. This review highlights the alterations in gut microbes and their metabolites in epileptic children, analyzes their impact on seizures, and explores potential associations.
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| http://dx.doi.org/10.1016/j.yebeh.2024.109899 | DOI Listing |
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