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| http://dx.doi.org/10.1001/jamainternmed.2024.2376 | DOI Listing |
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Global Brain Health Institute, University of California, San Francisco, CA, USA.
Background: The COVID-19 pandemic in Ethiopia posed additional challenges to an already strained mental health service. Eka Kotebe Hospital, the second-largest mental health facility with a capacity of 175 beds, was transformed into a dedicated COVID-19 treatment center, leaving mental health service users, especially vulnerable elderly patients with cognitive impairments, without adequate support. I had the challenge to implement alternatives to provide mental health services coverage to underserved elderly population.
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December 2024
Department of Chemistry, Texas A&M University College Station Texas 77843 USA
Despite the growing interest in mirror-image l-oligonucleotides, both as a robust nucleic acid analogue and as an artificial genetic polymer, their broader adoption in biochemical research and medicine remains hindered by challenges associated with the synthesis of long sequences, especially for l-RNA. Herein, we present a novel strategy for assembling long l-RNAs the joining of two or more shorter fragments using cross-chiral ligase ribozymes together with new substrate activation chemistry. We show that 5'-monophosphorylated l-RNA, which is readily prepared by solid-phase synthesis, can be activated by chemical attachment of a 5'-adenosine monophosphate (AMP) or diphosphate (ADP), yielding 5'-adenosyl(di- or tri-)phosphate l-RNA.
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Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA, USA.
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