AI Article Synopsis
- * The preferred surgical option, total colorectal resection with ileal pouch-anal anastomosis (IPAA), offers long-term relief but can lead to pouchitis, a common complication post-surgery.
- * Researchers used a microsurgery technique to create a pouchitis model in rats by inducing inflammation, allowing for the study of pouchitis and its treatment through various analyses.
Article Abstract
Ulcerative colitis (UC) is a chronic immune-mediated disease that affects the entire colon and rectum with a relapsing and remitting course, causing lifelong morbidity. When medical treatment is ineffective, especially in cases of massive gastrointestinal bleeding, perforation, toxic megacolon, or carcinogenesis, surgery becomes the last line of defense to cure UC. Total colorectal resection and ileal pouch-anal anastomosis (IPAA) offer the best chance for long-term treatment. Pouchitis is the most common and troublesome postoperative complication. In this investigation, microsurgery is employed to create an ileal pouch model in experimental rats via IPAA surgery. Subsequently, a sustained rat model of pouchitis is established by inducing inflammation of the ileal pouch with dextran sulfate sodium (DSS). The successful establishment of rat pouchitis is validated through analysis of postoperative general status, weight, food and water intake, fecal data, as well as pouch tissue pathology, immunohistochemistry, and inflammatory factor analysis. This experimental animal model of pouchitis provides a foundation for studying the pathogenesis and treatment of the condition.
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| http://dx.doi.org/10.3791/66623 | DOI Listing |
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