Previous studies have shown that the nucleus could offer structural support to the lens capsule. This study investigated the biomechanical performance of porcine lens with and without nucleus for 4 mm, 4.5 mm, 5 mm, 5.5 mm and 6 mm capsulotomy and its potential impact on the stretch ratio of capsular bag when the anterior capsulotomy edge was stretched. Our simulation results showed higher strain for the capsular bag with nucleus, which is crucial for the porcine lens to tolerate more stretch without failure. This simulation could support future study on the optimization of capsulotomy based on patient specific condition, that is, the geometry of lens.
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http://dx.doi.org/10.1080/10255842.2024.2364812 | DOI Listing |
Leg Med (Tokyo)
January 2025
Department of Forensic Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka, Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
Porcine eyes were examined using postmortem computed tomography (PMCT) under controlled postmortem time and temperature conditions to assess the mechanisms and timing of changes in ocular structure. Eight porcine heads were halved, and PMCT scans were conducted from postmortem interval (PMI) days 0 to 13. CT images were obtained to evaluate the vitreous volumes, vitreous CT values, axial lengths of the eyes, lens dislocation, and intraocular gas.
View Article and Find Full Text PDFTransl Vis Sci Technol
December 2024
Department of Biomedical Engineering, University of Houston, Houston, TX, USA.
Purpose: To assess the safety of acoustic radiation force optical coherence elastography in the crystalline lens in situ.
Methods: Acoustic radiation force (ARF) produced by an immersion single-element ultrasound transducer (nominal frequency = 3.5 MHz) was characterized using a needle hydrophone and used for optical coherence elastography (OCE) of the crystalline lens.
Front Ophthalmol (Lausanne)
December 2024
Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States.
Introduction: Accommodation is the process of changing the ocular lens' refractive power and focal distance. This process involves application of biomechanical forces on the lens by the surrounding musculature. Previous studies have demonstrated that the lens epithelium demonstrates mechanotransduction and that tension influences its chemical activity.
View Article and Find Full Text PDFACS Sens
December 2024
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Eyelid pressure is a crucial biomechanical parameter for ocular health and refractive status, yet measuring it poses challenges related to flexibility, sensitivity, and regional specificity. This study introduces a novel smart contact lens that incorporates kirigami designs and an iontronic capacitive sensing array to enhance flexibility and conformability. The unique structural composition of this device allows for precise and simultaneous monitoring of eyelid pressure in multiple regions with a high sensitivity and seamlessly fit across corneal curvatures.
View Article and Find Full Text PDFCornea
November 2024
St. Paul's Eye Unit, Department of Corneal Diseases, Royal Liverpool University Hospital, Liverpool, United Kingdom.
Purpose: To describe an early sterile keratolysis associated with a decellularized porcine corneal inlay implant for keratoconus.
Methods: This is a case report of a 23-year-old man with keratoconus who underwent lenticular intrastromal keratoplasty in his OD. Within 4 weeks, the patient presented with anterior sterile keratolysis and partial inlay extrusion, leading to surgical inlay removal.
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