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Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics. | LitMetric

AI Article Synopsis

  • * A study examined plasma from 50 individuals living with HIV to assess its ability to recognize and eliminate HIV-infected cells using a CD4mc, revealing significant variability among the samples.
  • * The effectiveness of plasma-mediated antibody-dependent cellular cytotoxicity (ADCC) in the presence of CD4mc was linked to specific antibodies targeting different parts of the HIV structure, including anti-cluster A and anti-gp41 cluster I antibodies.

Article Abstract

CD4-mimetics (CD4mcs) are small molecule compounds that mimic the interaction of the CD4 receptor with HIV-1 envelope glycoproteins (Env). Env from primary viruses normally samples a "closed" conformation which occludes epitopes recognized by CD4-induced (CD4i) non-neutralizing antibodies (nnAbs). CD4mcs induce conformational changes on Env resulting in the exposure of these otherwise inaccessible epitopes. Here we evaluated the capacity of plasma from a cohort of 50 people living with HIV to recognize HIV-1-infected cells and eliminate them by antibody-dependent cellular cytotoxicity (ADCC) in the presence of a potent indoline CD4mc. We observed a marked heterogeneity among plasma samples. By measuring the levels of different families of CD4i Abs, we found that the levels of anti-cluster A, anti-coreceptor binding site and anti-gp41 cluster I antibodies are responsible for plasma-mediated ADCC in presence of CD4mc.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177920PMC
http://dx.doi.org/10.1101/2024.06.02.24308281DOI Listing

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