Pharmacological Effect of Copper Oxide Nanoparticles of Leaf Extract and Application for its Antibacterial Properties.

Nanoparticles prepared from bio-reduction agents are of keen interest to researchers around the globe due to their ability to mitigate the harmful effects of chemicals. In this regard, the present study aims to synthesize copper oxide nanoparticles (CuO NPs). CuNPs show a characteristic absorption peak at 347 nm, while SEM reveals the spherical but agglomerated shape of CuNPs of the size within the range of 51.26-56.66 nm. The crystallite size measured by using XRD was found to be within a range of 23.38-46.64 nm for ginger-doped CuO and 26-56 nm for garlic-doped CuO. The X-ray diffraction analysis shows the crystalline structure of copper nanoparticles with prominent peaks. Bragg's reflection of copper nanoparticles shows diffraction peaks around 2θ =43.4°, 50.3°, and 74.39°, representing [111], [200], and [220] crystallographic planes of face-centered cubic (fcc). The synthesized CuO NPs tested antibacterial properties against various strains of microorganisms, including , 25 μg/mL 2.3 ± 0.21 and 100 μg/mL 6.5 ± 0.17, , 25 μg/mL 2.3 ± 0.29 and 100 μg/mL 11.5 ± 1.17, , 25 μg/mL 01.05 ± 0.21 and 100 μg/mL 15.8 ± 0.17, ). The short novelty of lies in its potential relevance to human health, as it has been found to possess bioactive compounds with various medicinal properties, such as antimicrobial, antioxidant, and anti-inflammatory activities, making it a promising natural resource for therapeutic applications.