AI Article Synopsis
- The study aimed to explore the role of cytokines in predicting the prognosis of interstitial lung disease (ILD) and to distinguish between different ILD subtypes.
- Researchers examined blood samples from 77 patients, measuring 27 cytokines and analyzing their association with disease progression using statistical methods.
- Findings revealed that higher levels of IL-13 correlated with slower disease progression, and several cytokines showed significant differences between fibrotic and inflammatory ILD types, suggesting IL-13 could serve as a potential biomarker for ILD stability.
Article Abstract
Purpose: Cytokines can help predict prognosis in interstitial lung disease (ILD) and to differentiate between ILD subtypes. The objectives of our study were to evaluate association of baseline cytokine levels with time to ILD progression and to compare baseline cytokine levels between ILD subtypes.
Methods: We quantified 27 cytokines using a multiplex assay in peripheral blood samples from 77 patients. Cox proportional hazards regression analysis was performed to evaluate cytokine impact on the time to progression in the total cohort and within each ILD type. We evaluated for significant differences in cytokine levels between ILD types using ANOVA, Wilcoxon signed-rank test and Tukey method.
Results: Higher IL-13 level was associated with longer time to progression (hazard ratio 0.52 [0.33-0.81], p-value 0.004). FGF-β, GM-CSF, and IL-17 levels differed significantly between fibrotic and inflammatory ILD subgroups.
Conclusion: IL-13 may be a useful biomarker predicting ILD stability.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11176841 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e32118 | DOI Listing |
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