An efficient, MnO-catalyzed ligand-free synthesis of ()-6,7-dihydrodibenzo[,][1,7]phenanthrolines, and ()-1,2,3,4-tetrahydrobenzo[][1,6]naphthyridines, utilizing, 2-amino-5-chloro-benzhydrol, acridinol, or 1-benzyl-4-piperidinol, , and benzyl alcohols, is reported. The MnO-catalyzed dehydrogenative Friedlander annulation utilizing ChCl/p-TSA (DES-1) and subsequent C(sp)-H functionalization with TBAB/p-TSA (DES-2) was effected at 100 °C. The optimized reaction conditions gave excellent product yields, and the products were evaluated for their by UV absorption and fluorescence emission studies.
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| http://dx.doi.org/10.1021/acsomega.4c00188 | DOI Listing |
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