Study of Highly Efficient Au/Pt Nanoparticles for Rapid Screening of .

ACS Omega

Institute of Material Science and Engineering, National Central University, No. 300, Zhong-da Rd. Zhongli District ,Taoyuan City 32001, Taiwan (R.O.C.).

Published: June 2024

This study synthesized core/shell gold-platinum nanoparticles and characterized their colorimetric properties; ultraviolet-visible spectroscopy revealed that the synthesized nanoparticles exhibited distinct colors from conventional gold nanoparticles. Furthermore, the nanoparticles were subjected to lateral flow assays using Protein A, and the results revealed that they outperformed conventional spherical gold nanoparticles in terms of color development. This improvement can be attributed to the distinct core/shell structures of our nanoparticles. Further evaluation revealed that these nanoparticles could facilitate the detection of Toxin B visually at an extremely low concentration (1 ng/mL) without the requirement for advanced instrumentation. This substantial improvement in sensitivity can be attributed to the meticulous design and nanoscale engineering of the structure of the nanoparticles.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11170621PMC
http://dx.doi.org/10.1021/acsomega.4c00722DOI Listing

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