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| http://dx.doi.org/10.11604/pamj.2024.47.135.42756 | DOI Listing |
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Impact of a high inspired oxygen fraction on oxidative stress in pediatric patients: reassuring results based on a randomized trial.
Med Gas Res
June 2025
Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
High-concentration oxygen inhalation is the primary intervention to prevent perioperative hypoxemia. However, there are concerns that this may induce an imbalance in oxidation‒reduction processes, particularly in pediatric patients with compromised antioxidant defenses. This study aimed to evaluate the impact of varying intraoperative concentrations of oxygen inhalation on oxidative stress in children by analyzing plasma biomarkers, oxygenation indices, and the duration of surgery and oxygen inhalation.
View Article and Find Full Text PDFCiprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin. Despite these advantages, ciprofol's clinical research is still emerging. This study compares the median effective dose (ED) and adverse reactions of ciprofol and propofol, in conjunction with sufentanil, for suppressing cardiovascular responses during tracheal intubation.
View Article and Find Full Text PDFInduction Agents for Tracheal Intubation in Critically Ill Patients.
Crit Care Med
January 2025
Department of Anesthesia and Critical Care, AOU S. Luigi Gonzaga, Orbassano, Turin, Italy.
Objectives: Concise definitive review of the use of induction agents in critically ill patients undergoing tracheal intubation and their association with outcomes.
Data Sources: Original publications were retrieved through a PubMed search with search terms related to induction agents for tracheal intubation in critically ill patients.
Study Selection: We included randomized controlled trials and observational studies that reported patient outcomes.
Inhibitory effect of low-dose esketamine on cough induced by sufentanil during the induction of anesthesia and postoperative impact on mental health status: a prospective, single-center, randomized controlled trial.
BMC Anesthesiol
December 2024
Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Background: Intravenous administration of sufentanil during anesthesia induction induces cough (SIC), sometimes triggers a severe reaction. We wanted to investigate the inhibitory effect of low-dose esketamine on cough induced by sufentanil during the induction of general anesthesia, as well as its postoperative impact on mental status (MMSE score, RSS, and VAS-A).
Methods: A total of 256 adult patients were randomly allocated to receive either esketamine (Group EK) or normal saline (Group C).
Clinical and swallowing characteristics of tracheostomized patients with post-intubation acquired tracheal or laryngotracheal stenosis.
Clinics (Sao Paulo)
December 2024
Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:
Article Synopsis
- The study examined patients with tracheal or laryngotracheal stenosis who required tracheostomy, focusing on their swallowing and clinical profiles before undergoing airway interventions.
- It involved a retrospective cohort study where patients underwent swallowing evaluations and imaging, with follow-ups at 6 and 12 months to assess progress.
- Results showed female predominance, high rates of subglottic stenosis, and that many had significant swallowing difficulties, indicating a need for personalized care due to potential complications affecting recovery.
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