Neuroparacoccidioidomycosis.

J Assoc Physicians India

Director ICU, Department of Intensive Care Unit, Ruby Hall Clinic, Pune, Maharashtra, India.

Published: June 2024

Paracoccidioidomycosis (PCM) is caused by a dimorphic fungus Paracoccidioides Brasiliensis and is endemic to subtropical areas of Central and South America. CNS involvement of PCM is extremely variable. NeuroPCM is found in 9.65% to 27.18% of PCM cases .Most neuro PCM patients presents with simultaneous involvement of other organ but isolated or initial CNS involvement may be a feature in 21%. Here we report a case of CNS PCM and this appears to be first reported case of PCM and CNS PCM in India.

Download full-text PDF

Source
http://dx.doi.org/10.59556/japi.72.0318DOI Listing

Publication Analysis

Top Keywords

cns involvement
8
cns pcm
8
pcm
7
neuroparacoccidioidomycosis paracoccidioidomycosis
4
paracoccidioidomycosis pcm
4
pcm caused
4
caused dimorphic
4
dimorphic fungus
4
fungus paracoccidioides
4
paracoccidioides brasiliensis
4

Similar Publications

Background: The pressure gradient between the ventricles and the subarachnoid space (transmantle pressure) is crucial for understanding CSF circulation and the pathogenesis of certain neurodegenerative diseases. This pressure can be approximated by the pressure difference across the aqueduct (ΔP). Currently, no dedicated platform exists for quantifying ΔP, and no research has been conducted on the impact of breathing on ΔP.

View Article and Find Full Text PDF

The relationship between cannabis use and mental health is complex, as studies often report seemingly contradictory findings regarding whether cannabis use results in more positive or negative treatment outcomes. With an increasing number of individuals using cannabis for both recreational (i.e.

View Article and Find Full Text PDF

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by hallmark pathologies that affect many brain regions, including the cellular microenvironment with the hippocampus, ultimately leading to profound deficits in cognition. Surprising recent work has shown that factors in the systemic environment regulate the hippocampal cellular niche; age-associated blood-borne factors exacerbate brain aging phenotypes, whereas youth-associated blood-borne factors, including tissue inhibitor of metalloproteinases 2 (TIMP2), reverse or ameliorate features of brain aging. As aging serves as the major risk factor for AD, and recent work shows that systemic factors can regulate AD pathology, we sought to characterize mechanisms by which the systemic environment regulates CNS phenotypes relevant to AD pathology through changes in neuroinflammation.

View Article and Find Full Text PDF

Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

VA Boston Healthcare System, Boston, MA, USA.

Background: T-cell infiltration into the brain parenchyma is associated with hyperphosphorylated tau (p-tau) accumulation in neurodegenerative diseases. Chronic traumatic encephalopathy (CTE) is a progressive tauopathy caused by exposure to repetitive head impacts (RHI). CTE is defined by the perivascular accumulation of p-tau at the cortical sulcal depths and can be stratified into mild and severe pathological stages.

View Article and Find Full Text PDF

Background: The characterization of intercellular communication between peripheral immune cells and the central nervous system (CNS) are essential for understanding the brain's response to aging and disease states, such as Alzheimer's disease. MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that play a crucial role in regulating various biological and pathological processes, including those related to immunity and inflammation. MiR-223-3p, residing on the X chromosome, is a pivotal miRNA involved in the inflammatory response, with its expression being enriched in macrophages/microglia.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!