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Spinal nerve ligation: An experimental model to study neuropathic pain in rats and mice. | LitMetric

Spinal nerve ligation: An experimental model to study neuropathic pain in rats and mice.

Methods Cell Biol

Department of Pharmacology, University of Vermont, Burlington, VT, United States; Department of Physiology, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain. Electronic address:

Published: June 2024

AI Article Synopsis

  • * It poses significant economic and emotional challenges, highlighting the urgent need for better treatment options due to current ineffective pharmacological solutions and side effects.
  • * The chapter details a widely used spinal nerve ligation (SNL) model in rodents to study neuropathic pain, outlining the surgical procedure and methods for assessing pain behaviors.

Article Abstract

Neuropathic pain, defined as the most terrible of all tortures, which a nerve wound may inflict, is a common chronic painful condition caused by gradual damage or dysfunction of the somatosensory nervous system. As with many chronic diseases, neuropathic pain has a profound economic and emotional impact worldwide and represents a major public health issue from a treatment standpoint. This condition involves multiple sensory symptoms including impaired transmission and perception of noxious stimuli, burning, shooting, spontaneous pain, mechanical or thermal allodynia and hyperalgesia. Current pharmacological options for the treatment of neuropathic pain are limited, ineffective and have unacceptable side effects. In this framework, a deeper understanding of the pathophysiology and molecular mechanisms associated with neuropathic pain is key to the development of promising new therapeutical approaches. For this purpose, a plethora of experimental models that mimic common clinical features of human neuropathic pain have been characterized in rodents, with the spinal nerve ligation (SNL) model being one of the most widely used. In this chapter, we provide a detailed surgical procedure of the SNL model used to induce neuropathic pain in rats and mice. We further describe the behavioral approaches used for stimulus-evoked and spontaneous pain assessment in rodents. Finally, we demonstrate that our SNL model induces multiple pain behaviors in rats and mice.

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Source
http://dx.doi.org/10.1016/bs.mcb.2024.03.006DOI Listing

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