AI Article Synopsis
- - This study focuses on creating a new type of hernia mesh made from siloxane-modified bacterial cellulose to improve adhesion prevention and abdominal wall repair while ensuring good compatibility with human tissues.
- - Researchers used chemical vapor deposition to modify bacterial cellulose and tested how different lengths of alkyl chains affected the material's surface properties and the behavior of cells.
- - Results indicated that the longest alkyl chain version, BC-C16, displayed excellent long-term effectiveness in preventing adhesions and showed favorable tissue compatibility, making it a promising candidate for clinical use in hernia repairs.
Article Abstract
Abdominal hernia mesh is a common product which is used for prevention of abdominal adhesion and repairing abdominal wall defect. Currently, designing and preparing a novel bio-mesh material with prevention of adhesion, promoting repair and good biocompatibility simultaneously remain a great bottleneck. In this study, a novel siloxane-modified bacterial cellulose (BC) was designed and fabricated by chemical vapor deposition silylation, then the effects of different alkyl chains length of siloxane on surface properties and cell behaviors were explored. The effect of preventing of abdominal adhesion and repairing abdominal wall defect in rats with the siloxane-modified BC was evaluated. As the grafted alkyl chains become longer, the surface of the siloxane-modified BC can be transformed from super hydrophilic to hydrophobic. In vivo results showed that BC-C16 had good long-term anti-adhesion effect, good tissue adaptability and histocompatibility, which is expected to be used as a new anti-adhesion hernia repair material in clinic.
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| http://dx.doi.org/10.1016/j.ijbiomac.2024.133191 | DOI Listing |
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