AI Article Synopsis
- Chemotherapy is an important treatment for colorectal cancer, but some cancers become resistant to it.
- New research shows that when cancer cells are treated with drugs that damage DNA, a part of the cell called the Golgi disperses more in cancer stem cells than in regular cancer cells.
- This Golgi dispersal helps the cancer cells resist the effects of the drugs by making it easier for them to move chemicals out of the cells, revealing a new way that cancer can become resistant to treatment.
Article Abstract
Chemotherapy is a crucial treatment for colorectal tumors. However, its efficacy is restricted by chemoresistance. Recently, Golgi dispersal has been suggested to be a potential response to chemotherapy, particularly to drugs that induce DNA damage. However, the underlying mechanisms by which Golgi dispersal enhances the capacity to resist DNA-damaging agents remain unclear. Here, we demonstrated that DNA-damaging agents triggered Golgi dispersal in colorectal cancer (CRC), and cancer stem cells (CSCs) possessed a greater degree of Golgi dispersal compared with differentiated cancer cells (non-CSCs). We further revealed that Golgi dispersal conferred resistance against the lethal effects of DNA-damaging agents. Momentously, Golgi dispersal activated the Golgi stress response via the PKCα/GSK3α/TFE3 axis, resulting in enhanced protein and vesicle trafficking, which facilitated drug efflux through ABCG2. Identification of Golgi dispersal indicated an unexpected pathway regulating chemoresistance in CRC.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180190 | PMC |
| http://dx.doi.org/10.1038/s41419-024-06817-0 | DOI Listing |
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