Calcium β-hydroxy-β-methylbutyrate (CaHMB), a functional calcium salt, is used to maintain and improve muscle health. Here, a new hydrogel material prepared from alginate (ALG) with three M/G ratios (1:1, 2:1, and 1:2) and CaHMB (0-2 mg/mL) was investigated. CaHMB regulates the formation and properties of ALG hydrogels through chelation and hydrogen bonding. When the M/G ratio was 2:1, the anionic groups of CaHMB containing carboxyl and hydroxyl groups formed hydrogen bonds with the polysaccharide chains, hindering the capture of Ca by the G-residue fragments of ALG, which in turn retarded the gelation process. The noncalcium cross-linked polysaccharide chain structure of ALG and the anionic group of CaHMB also affected the water distribution in the hydrogel, especially when M residue content ≥G residue content. Lower M/G ratios and higher CaHMB concentrations could increase the number of "egg box" crosslinking junctions of calcium alginate, and the microstructure was denser in the gel pores, resulting in a stronger gel strength and more free water bound in the gel matrix. This study provides a theoretical and methodological basis for the design of novel hydrogels by studying the crosslinking features of ALG/CaHMB.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2024.133162 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender.
Arthritis Res Ther
January 2025
Department of Biomedical Sciences, Humanitas University, Via R Levi Montalcini 4, Pieve Emanuele, Milan, 20090, Italy.
Background: There is still a significant proportion of patients with rheumatoid arthritis (RA) in whom multiple therapeutic lines are ineffective. These cases are defined by the EULAR criteria as Difficult-to-Treat RA (D2T-RA) for which there is limited knowledge of predisposing factors.
Objective: To identify the clinical features associated with D2T-RA in real-life practice.
Sex-Based Differences in Endovascular Thrombectomy Outcomes for Large Ischemic Stroke: A SELECT2 Subanalysis.
Stroke
January 2025
Neurology, Stroke, University Hospital Cleveland Medical Center - Case Western Reserve University, OH. (A.O., C.S., A.S.).
Background: Several social and biological factors are shown to differentially affect stroke outcomes between men and women. We evaluated whether clinical outcomes and endovascular thrombectomy (EVT) treatment effects differed between the sexes in patients presenting with large ischemic stroke.
Methods: The SELECT2 trial (A Randomized Controlled Trial to Optimize Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke) was a randomized controlled trial assessing the efficacy and safety of EVT in patients with large strokes across the United States, Canada, Europe, Australia, and New Zealand between October 2019 and September 2022.
Effect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial.
Neurology
January 2025
From the Center for Stroke Research Berlin (I.G., J.B.F.), Charité-Universitätsmedizin Berlin, Germany; Service de Biostatistique (F.B., P.R.), Hospices Civils de Lyon, France; Department of Neurology (B.C., C.G., G.T.), University Medical Center Hamburg-Eppendorf, France; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, Hospices Civils de Lyon, France; Neurologie der Rehaklinik Medical Park Humboldtmühle (M. Ebinger), Berlin; Klinik und Hochschulambulanz für Neurologie (M. Endres), Charité-Universitätsmedizin Berlin; Center for Stroke Research Berlin (M. Endres); German Center for Neurodegenerative Diseases (DZNE), partner site Berlin (M. Endres); German Centre for Cardiovascular Research (DZHK), partner site Berlin (M. Endres); German Center for Mental Health (DZPG), partner site Berlin (M. Endres), Germany; Department of Neurology (C.E.), Medical University of Graz, Austria; Department of Diagnostic and Interventional Neuroradiology (J.F.), Universitätsklinikum Hamburg-Eppendorf, Germany; Robertson Centre for Biostatistics (I.F.), University of Glasgow, Scotland; mediri GmbH (J.G.); Fraunhofer Institute for Digital Medicine MEVIS (M.G.), Bremen, Germany; Department of Neurosciences (R.L., A.W.), Experimental Neurology, KU Leuven-University of Leuven, Belgium; School of Psychology & Neuroscience (K.W.M.), University of Glasgow, Scotland; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Florey Institute of Neuroscience and Mental Health (V.N.T.), Heidelberg, Australia; and Institut d'Investigació Biomèdica de Girona (S.P.), Hospital Universitari Doctor Josep Trueta, Girona, Spain.
Background And Objectives: Data from randomized trials on the treatment effect of pure thrombolysis in patients with vessel occlusion are lacking. We examined data from a corresponding subsample of patients from the multicenter, randomized, placebo-controlled WAKE-UP trial to determine whether MRI-guided IV thrombolysis with alteplase in unknown-onset ischemic stroke benefits patients presenting with vessel occlusion.
Methods: Patients with an acute ischemic lesion visible on MRI diffusion-weighted imaging but no marked parenchymal hyperintensity on fluid-attenuated inversion recovery images were randomized to treatment with IV alteplase or placebo.
Prevalence of Mitral Annular Disjunction at Cardiac MRI: Results from a Multicenter Registry.
Radiol Cardiothorac Imaging
December 2024
From the Department of Radiology, School of Medicine, Vita-Salute San Raffaele University, Via Olgettina 58-60, 20132 Milan, Italy (A. Palmisano, E.B., S.B., D.V., A.E.); Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, Italy (A. Palmisano, E.B., M.C., D.V., A.E.); Academic Radiology Department of Translational Research, University of Pisa, Pisa, Italy (G.D.A., C.D.G., M.A., D.P., L.F., E.N.); Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Department of Radiodiagnostics, Università di Brescia-Spedali Civili, Brescia, Italy (P.R., N.d.M., M.R., D.F.); Department of Emergency Radiology, University Hospital Careggi, Florence, Italy (A.R., S.P., V.M.); Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italy (L.M., G.C., N.G.); Department of Surgical Sciences, University of Turin, Turin, Italy (D.T., M.G., R.F.); Department of Diagnostic Imaging, Area of Cardiovascular and Interventional Imaging, Abruzzo Health Unit 1, L'Aquila, Italy (P.P.); Department of Biotechnological and Applied Clinical Science, University of L'Aquila, L'Aquila, Italy (E.D.C.); Diagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital Policlinico, Messina, Italy (T.D., L.R.M.L., A.B.); Department of Radiology, Santa Maria delle Grazie Hospital, Pozzuoli, Italy (S.D.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (A. Ponsiglione, R.A., M.I.); Department of Radiology, AOU Cagliari, University of Cagliari, Cagliari, Italy (M.P., R.C., L.S.); Department of Radiology, Ospedale del Mare-ASL NA1 Centro, Naples, Italy (G.F., C.L.); Department of Radiology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy (V.S., S.S.); Department of Radiology, Ospedale Maggiore della Carità University Hospital, Novara, Italy (A.S., A.C.); and IRCCS Azienda Ospedaliero-Universitaria di Bologna, S. Orsola Hospital, University of Bologna, Italy (L.L.).
Purpose To determine the prevalence of mitral annular disjunction (MAD) in patients undergoing cardiac MRI for various clinical indications and to assess the association of MAD with arrhythmia, mitral valve prolapse (MVP), and myocardial alteration. Materials and Methods This study analyzed data from a retrospective observational registry of consecutive patients undergoing cardiac MRI for different clinical indications. Cardiac MRI examinations were performed from January 2019 to June 2019 at 13 Italian hospitals.
View Article and Find Full Text PDF7T MRI as a powerful tool to detect small and medium size vessel CNS vasculitis.
AJNR Am J Neuroradiol
December 2024
Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland (A.H., W.A., A.B.,R.W., P.R.), Department of Neuroradiology, Kantonsspital Aarau, Aarau, Switzerland (P.M.), Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland (D.J.S.,M.G., M.R.H.), Institute of Radiology, Clinic Maennedorf, Maennedorf, Zurich, Switzerland (E.J.), Department of Neurology, RHNe, Hôpital Pourtalès, Neuchâtel, Switzerland (P.M.), Department of Rheumatology, Inselspital, University of Bern, Bern, Switzerland (L.C.) Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland (R.W., P.R.).
Imaging can help to diagnose CNS vasculitis. Yet so far, no imaging studies of CNS vasculitis at 7T are available. We share our experience of vessel wall imaging (VWI) at 7T in patients with suspected vasculitis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!