Hedgehog and antihedgehog spin textures in magnets behave as emergent monopoles and antimonopoles, which give rise to astonishing transport and electromagnetic phenomena. Using the Kondo-lattice model in three dimensions, we theoretically study collective spin-wave excitation modes of magnetic hedgehog lattices which have recently been discovered in itinerant magnets such as MnSi_{1-x}Ge_{x} and SrFeO_{3}. It is revealed that the spin-wave modes, which appear in the subterahertz regime, have dominant amplitudes localized at Dirac strings connecting hedgehog-antihedgehog pairs and are characterized by their translational oscillations. It is found that their spectral features sensitively depend on the number and configuration of the Dirac strings and, thus, can be exploited for identifying the topological phase transitions associated with the monopole-antimonopole pair annihilations.
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http://dx.doi.org/10.1103/PhysRevLett.132.226705 | DOI Listing |
Curr Drug Targets
January 2025
Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar (M.P.) 470003, India.
Breast cancer remains the second most prevalent cancer among women in the United States. Despite advancements in surgical, radiological, and chemotherapeutic techniques, multidrug resistance continues to pose significant challenges in effective treatment. Combination chemotherapy has emerged as a promising approach to address these limitations, allowing multiple drugs to target malignancies via distinct mechanisms of action.
View Article and Find Full Text PDFNeuroradiol J
November 2024
Diagnostic Radiology, College of Medicine, Clinical Affairs, King Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia.
The World Health Organization (WHO) subdivided medulloblastoma into genetic and histopathological groups, each with a specific therapeutic intervention and different clinical outcomes. These subtypes may present with distinct imaging features. Therefore, the current study aimed to identify magnetic resonance imaging (MRI) biomarkers to predict the precise pathological characteristics of medulloblastoma.
View Article and Find Full Text PDFMov Disord Clin Pract
November 2024
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Background: Reduced cerebrospinal fluid (CSF) clearance may play a vital role in the pathogenesis of normal pressure hydrocephalus (NPH), but the radiologic marker is yet to be elucidated.
Objectives: This open-label study presents two novel neuroimaging biomarkers based on enlarged perivascular spaces (ePVS) of the sub-insular territory: the Hedgehog and Hedgehog-Halo (H-H) sign, designed to predict gait symptom severity and tap response in NPH.
Methods: We retrospectively reviewed 203 patients with possible NPH with baseline magnetic resonance imaging and gait analyses before and after lumbar puncture (LP).
Anal Chem
October 2024
College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun 130012, China.
Front Neurosci
September 2024
Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volumes in the cerebrum, cerebellum, and cerebral ventricles, suggesting the association between brain morphology and the constitutive hyperactivation of hedgehog signaling, while the changes of regional brain volumes in upregulated hedgehog signaling pathway remains unclear so far. Herein, we investigated comprehensive brain regional volumes using quantitative structural brain MRI, and identified increased volumes of amygdala, striatum, and pallidum on the global segmentation, and increased volumes of the lateral and medial parts of the central nucleus of the amygdala on the detail segmentation in heterozygous deletion mice.
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