AI Article Synopsis
- Implantable silicon neural probes have been developed with nanophotonic grating emitters that focus light for precise optogenetic neuron targeting.
- Gratings were specifically designed for wavelengths of 488 and 594 nm to excite Channelrhodopsin-2 and Chrimson, key optogenetic actuators.
- This is the first documented instance of creating focused light spots at the scale of neuron cell bodies within brain tissue using these neural probes.
Article Abstract
We have designed, fabricated, and characterized implantable silicon neural probes with nanophotonic grating emitters that focus the emitted light at a specified distance above the surface of the probe for spatially precise optogenetic targeting of neurons. Using the holographic principle, we designed gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The measured optical emission pattern of these emitters in non-scattering medium and tissue matched well with simulations. To our knowledge, this is the first report of focused spots with the size scale of a neuron soma in brain tissue formed from implantable neural probes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11178810 | PMC |
| http://dx.doi.org/10.1038/s41598-024-64037-0 | DOI Listing |
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