AI Article Synopsis
- Scientists found a special substance from a fungus called Chaetomium nigricolor that might help fight cancer!
- They figured out that this substance is a fatty acid called Nonacosenoic acid, and tested it on different types of cells.
- The tests showed it's good at harming cancer cells but not so much at harming healthy cells, which is pretty interesting!
Article Abstract
The endophytic fungus Chaetomium nigricolor culture filtrate's hexane extract was used to identify a cytotoxic very long-chain fatty acid. Based on multiple spectroscopic investigations, the structure of the compound was predicted to be an unsaturated fatty acid, Nonacosenoic acid (NA). Using the MTT assay, the compound's cytotoxic potential was evaluated against MCF-7, A-431, U-251, and HEK-293 T cells. The compound was moderately cytotoxic to breast carcinoma cell line, MCF-7 cells and negligibly cytotoxic to non-cancerous cell line HEK-293 T cells. The compound exhibited mild cytotoxic activity against A-431 and U-251 cells. The compound also induced ROS generation and mitochondrial depolarization in MCF-7 cells when assessed via the NBT and JC-1 assays, respectively. This is the first report on the production of nonacosenoic acid from the endophytic fungus Chaetomium nigricolor and the assessment of its bioactivity.
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| http://dx.doi.org/10.1016/j.funbio.2024.05.008 | DOI Listing |
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