AI Article Synopsis
- Artemisia argyi is a medicinal plant known for its health benefits due to its various triterpenoids that have anti-viral, anti-cancer, and anti-oxidant properties.
- The study focuses on isolating and identifying four genes related to the 2,3-oxidosqualene cyclase (OSC) family, which are crucial for the triterpenoid biosynthesis pathway in A. argyi.
- Three of the isolated OSC genes were shown to produce different triterpenoids through a yeast expression system, enhancing knowledge of how these valuable compounds are synthesized in the plant.
Article Abstract
Artemisia argyi is a traditional medicinal and edible plant, generating various triterpenoids with pharmacological activities, such as anti-virus, anti-cancer, and anti-oxidant. The 2,3-oxidosqualene cyclase family of A. argyi offers novel insights into the triterpenoid pathway, which might contribute to the medicinal value of its tissue extracts. Nevertheless, the biosynthesis of active triterpenoids in Artemisia argyi is still uncertain. In this study, four putative OSC (2,3-oxidosqualene cyclase) genes (AaOSC1-4) were first isolated and identified from A. argyi. Through the yeast heterologous expression system, three AaOSCs were characterized for the biosynthesis of diverse triterpenoids including cycloartenol, β-amyrin, (3S,13R)-malabarica-14(27),17,21-trien-3β-ol, and dammara-20,24-dien-3β-ol. AaOSC1 was a multifunctional dammara-20,24-dien-3β-ol synthase, which yielded 8 different triterpenoids, including tricyclic, and tetracyclic products. AaOSC2 and AaOSC3 were cycloartenol, and β-amyrin synthases, respectively. As a result, these findings provide a deeper understanding of the biosynthesis pathway of triterpenes in A. argyi.
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| http://dx.doi.org/10.1016/j.pep.2024.106533 | DOI Listing |
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