AI Article Synopsis
- The endometrial receptivity is essential for embryo implantation and successful pregnancy, making it a key focus in fertility treatments like IVF.
- Long non-coding RNAs (lncRNAs) are important gene regulators that influence endometrial receptivity, with numerous lncRNAs identified in humans and other species that could modulate this process.
- Future research should investigate the potential of lncRNAs as targets for therapy and as biomarkers to enhance endometrial receptivity in fertility treatments.
Article Abstract
The development of endometrial receptivity is crucial for successful embryo implantation and the initiation of pregnancy. Understanding the molecular regulatory processes that transform the endometrium into a receptive phase is essential for enhancing implantation rates in fertility treatments, such as in vitro fertilization (IVF). Long non-coding RNAs (lncRNAs) play a pivotal role as gene regulators and have been examined in the endometrium. This review offers current insights into the role of lncRNAs in regulating endometrial receptivity. Considering the significant variation in endometrial remodeling among species, we summarize the key events in the human endometrial cycle and discuss the identified lncRNAs in both humans and other species, which may play a crucial role in establishing receptivity. Notably, there are 742 lncRNAs in humans and 4438 lncRNAs that have the potential to modulate endometrial receptivity. Additionally, lncRNAs regulating matrix metalloproteinases (MMPs) and Let-7 have been observed in both species. Future investigations should explore the potential of lncRNAs as therapeutic targets and/or biomarkers for diagnosing and improving endometrial receptivity in human fertility therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349255 | PMC |
| http://dx.doi.org/10.5935/1518-0557.20240038 | DOI Listing |
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