Cheek and Johnston (JMB 86:70, 2023) consider a continuous-time Bienaymé-Galton-Watson tree conditioned on being alive at time T. They study the reproduction events along the ancestral lineage of an individual randomly sampled from all those alive at time T. We give a short proof of an extension of their main results (Cheek and Johnston in JMB 86:70, 2023, Theorems 2.3 and 2.4) to the more general case of Bellman-Harris processes. Our proof also sheds light onto the probabilistic structure of the rate of the reproduction events. A similar method will be applied to explain (i) the different ancestral reproduction bias appearing in work by Geiger (JAP 36:301-309, 1999) and (ii) the fact that the sampling rule considered by Chauvin et al. (SPA 39:117-130, 1991), (Theorem 1) leads to a time homogeneous process along the ancestral lineage.
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http://dx.doi.org/10.1007/s00285-024-02105-9 | DOI Listing |
J Math Biol
June 2024
Institut für Mathematik, Goethe-Universität Frankfurt, Robert-Mayer-Str. 10, Frankfurt am Main, 60325, Hessen, Germany.
Cheek and Johnston (JMB 86:70, 2023) consider a continuous-time Bienaymé-Galton-Watson tree conditioned on being alive at time T. They study the reproduction events along the ancestral lineage of an individual randomly sampled from all those alive at time T. We give a short proof of an extension of their main results (Cheek and Johnston in JMB 86:70, 2023, Theorems 2.
View Article and Find Full Text PDFNeurosurgery
November 2024
Department of Neurosurgery, University of Alabama at Birmingham, Birmingham , Alabama , USA.
Background And Objectives: Vein of Galen malformation (VOGM), the result of arteriovenous shunting between choroidal and/or subependymal arteries and the embryologic prosencephalic vein, is among the most severe cerebrovascular disorders of childhood. We hypothesized that in situ analysis of the VOGM lesion using endoluminal tissue sampling (ETS) is feasible and may advance our understanding of VOGM genetics, pathogenesis, and maintenance.
Methods: We collected germline DNA (cheek swab) from patients and their families for genetic analysis.
J Exp Med
July 2023
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
The oral mucosa is a frontline for microbial exposure and juxtaposes several unique tissues and mechanical structures. Based on parabiotic surgery of mice receiving systemic viral infections or co-housing with microbially diverse pet shop mice, we report that the oral mucosa harbors CD8+ CD103+ resident memory T cells (TRM), which locally survey tissues without recirculating. Oral antigen re-encounter during the effector phase of immune responses potentiated TRM establishment within tongue, gums, palate, and cheek.
View Article and Find Full Text PDFJ Math Biol
April 2023
Department of Mathematics, King's College London, Strand Building, London, WC2R 2LS, UK.
Consider a branching process whose reproduction law is homogeneous. Sampling a single cell uniformly from the population at a time [Formula: see text] and looking along the sampled cell's ancestral lineage, we find that the reproduction law is heterogeneous-the expected reproductive output of ancestral cells on the lineage from time 0 to time T continuously increases with time. This 'inspection paradox' is due to sampling bias, that cells with a larger number of offspring are more likely to have one of their descendants sampled by virtue of their prolificity.
View Article and Find Full Text PDFHCA Healthc J Med
June 2020
River Ridge Dermatology, Blacksburg, VA.
Introduction: Red Ear Syndrome (RES) is a condition often considered to be a localized form of erythromelalgia. It can be related to structural cervical defects or idiopathic. RES is generally very difficult to treat.
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